HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → HCID 70619511, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-({2-[4-Phenyl-4-(propanoyloxy)piperidin-1-yl]ethyl}amino)benzene-1-carboximidic acid | HCID 3050170 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 70619511 | HCID 70619511 | — |
Reaction Steps
A mixture of 2-[2-(4-propionoxy-4-phenylpiperidino)ethylamino]benzamide (12.55 g), benzaldehyde (3.55 g), piperidine (1.35 g), and absolute ethanol (80 ml) was refluxed for 30 hrs. The solvent was removed on a rotovap. The thick oily product was chromatographed using silica gel and 5% isopropanol in chloroform. The product was isolated and dissolved in 30 ml 95% ethanol The solution was made acid with 4N H2SO4 and then 90 ml H2O was added. After 1 hr, the product was isolated and recrystallized from 850 ml 95% ethanol; yield 8.7 g, m.p. 186°-189° (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04085107 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-04c6ff51afa4428f949433ffa37e1351 |
| Source note | uspto-grants-1978_04 |