8-methylsulfonyl-12(R)-hydroxy-10-heptadecynoic acid → 8-methylsulfonyl-12(R)-hydroxyheptadecanoic acid

HRID 2083296Notes

Reaction equation

HRID 2083296 reaction equation
[CH3:1][S:2]([CH:5]([CH2:15][C:16]#[C:17][C@@H:18]([OH:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])(=[O:4])=[O:3].CS(C(CC#C[C@H](O)CCCCC)CCCCCCC(O)=O)(=O)=O>>[CH3:1][S:2]([CH:5]([CH2:15][CH2:16][CH2:17][C@H:18]([OH:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 227969748-methylsulfonyl-12(R)-hydroxy-10-heptadecynoic acidHCID 227969758-methylsulfonyl-12(S)-hydroxy-10-heptadecynoic acid

Product 1

HCID 227969778-methylsulfonyl-12(R)-hydroxyheptadecanoic acid

Procedure

The synthesis of this compound is carried out by the procedure described in Example 15 except that the 8-methylsulfonyl-12(S)-hydroxy-10-heptadecynoic acid is replaced by an equivalent quantity of 8-methylsulfonyl-12(R)-hydroxy-10-heptadecynoic acid.

Workup

  1. customThe synthesis of this compound

Sources & evidence

ORD record
ord-d993ebeab2584766821ba823d03ae502
Source dataset
uspto-grants-1978_04
Patent number
US04085125

Reaction notes

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