Acetone → (3-trifluoromethyl-phenoxy)-acetaldehyde

HRID 2083313Notes

Reaction equation

HRID 2083313 reaction equation
C([O:3][CH:4](OCC)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)C.CC(C)=O.S(=O)(=O)(O)O>O>[F:14][C:13]([F:15])([F:16])[C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[O:6][CH2:5][CH:4]=[O:3]

Participants

5

Reactant 3

HCID 180AcetoneHCID 1118Sulfuric AcidHCID 126618001-(2,2-Diethoxyethoxy)-3-(trifluoromethyl)benzene

Product 1

HCID 11252687(3-trifluoromethyl-phenoxy)-acetaldehyde

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-trifluoromethylphenoxyacetaldehyde diethyl acetal (146.3 g.; 0.527 mole), acetone (600 ml.), water (550 ml.), and concentrated sulfuric acid (3.5 ml.) is heated under reflux for 22 hours.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 22 hours

Sources & evidence

ORD record
ord-340fdaf6c7554ab69a28ad981b931bef
Source dataset
uspto-grants-1978_04
Patent number
US04085125

Reaction notes

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