tert-Butyl isocyanate → HCID 178478853, compound

HRID 2083369Notes

Reaction equation

C([N:5]=C=[O:7])(C)(C)C.O.[NH2:9][C:10]1[C:11]([C:18]([N:20]=[CH:21][NH:22]NC(NC(C)(C)C)=O)=[O:19])=[N:12][C:13]([Cl:17])=[C:14]([NH2:16])[N:15]=1.[NH2:31][C:32]1[C:33]([C:40]([N:42]=[CH:43][NH:44][NH:45][C:46]([NH:48]C(C)(C)C)=[O:47])=[O:41])=[N:34][C:35]([Cl:39])=[C:36]([NH2:38])[N:37]=1>>[OH2:7].[ClH:17].[NH2:31][C:32]1[C:33]([C:40]([N:42]=[C:43]([NH:44][C:18]([NH2:20])=[O:19])[NH2:5])=[O:41])=[N:34][C:35]([Cl:39])=[C:36]([NH2:38])[N:37]=1.[NH2:9][C:10]1[C:11]([C:18]([N:20]=[C:21]([NH2:22])[NH:45][C:46]([NH2:48])=[O:47])=[O:19])=[N:12][C:13]([Cl:17])=[C:14]([NH2:16])[N:15]=1.[ClH:17]

Participants

Reactant 2

HCID 62412tert-Butyl isocyanate

HCID 178449604HCID 178449604, compound

Product 1

HCID 178478853HCID 178478853, compound

Procedure

Following the procedure of Example 23, Steps A and B but using the following pyrazinecarboxamides in place of the pyrazinecarboxamide used in Example 23, Step A, but using an equivalent amount of t-butylisocyanate and then following the procedure of Example 23B but using the appropriate pyrazinecarboxamide from Step A of that example the appropriate end product as listed is obtained.

Workup

customas listed is obtained

Sources & evidence

ORD record: ord-870047f1e2e14aee8ae45d3d10ff0aa8
Source dataset: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04085211

Reaction notes

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