HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Sulfide → 3,8-Dimethyl-5,6,7,8-tetrahydroquinoline-8-carbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Sulfide | HCID 402 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 8-Quinolinecarbonitrile, 5,6,7,8-tetrahydro-3,8-dimethyl- | HCID 12351931 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3,8-Dimethyl-5,6,7,8-tetrahydroquinoline-8-carbothioamide | HCID 12351900 | — |
Reaction Steps
3,8-dimethyl-8-cyano-5,6,7,8-tetrahydroquinoline is treated with H2S in pyridine in the presence of triethylamine following the general procedure of Example 5 and the title compound is isolated and recrystallised from benzene as the quarter hydrate, colourless meedles m.p. 164° C. This was converted to the hydrochloride by treatment in isopropanol with a solution of dry HCl gas in ether. The title compound hydrochloride crystallised as colourless needles m.p. 277° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04085215 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-761637bc43644e1cac646b2edc6fca6f |
| Source note | uspto-grants-1978_04 |