HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Cyclopentyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromocyclopentane | HCID 8728 | — |
| Reactant | 2-Methyl-5-methoxy-6,7-dichloro-1-indanone | HCID 12395561 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 2-Cyclopentyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone | HCID 12395568 | — |
Reaction Steps
A solution of 2-methyl-5-methoxy-6,7-dichloro-1-indanone (7.35 g., 0.03 mole) in tert.-butyl alcohol (100 ml.) is refluxed in an inert atmosphere and treated with potassium tert.-butoxide (4.48 G., 0.04 mole). After one-half hour at reflux cyclopentyl bromide (9.9 g., 0.06 mole) is added and refluxing is continued for 1 hour. The reaction is poured into water (1 l.) affording 2-cyclopentyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone which melts at 109°-111° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04085219 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-66b0ca0719ee489e81dd0729b183377b |
| Source note | uspto-grants-1978_04 |