Methylhydrazine → HCID 131711075, compound

Participants

Reaction Steps

A solution of 10.7 g of 2-[(dimethylamino)methyl]-2-phenyl-6-(phenylmethylene)cyclohexanone, monohydrochloride in 70 ml of methanol is treated with 1.5 g of methylhydrazine and the resulting solution is refluxed for 4 hours. The solution is cooled and the solvent is removed on a rotary evaporator to give 13.7 g of a semi-crystalline solid residue, which is crystallized from 30 ml of isopropanol to give 4.2 g of the title compound, melting point 225°-227° C (dec.). An additional 0.77 g of product is recovered from the filtrate giving a total yield of 4.97 g of the title compound, melting point 225°-227° C. Recrystallization of 5.6 g of this material from 100 ml of isopropanol gives 4.8 g of product, melting point 225°-227° C (dec.).

Provenance & Evidence