HCID 20357035, compound → HCID 20356998, compound

Participants

Reaction Steps

5-Chloromethyl-1,3,4-thiadiazol-2-yl isocyanate dimer (0.05 mole), the dimethyl acetal of 2-chloromethylamino-3-methoxypropionaldehyde (0.1 mole) and benzene (60 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux for a period of about 30 minutes. After this time the mixture is stripped of benzene under reduced pressure to yield a solid product as the residue. This residue is then recrystallized to yield the desired product the dimethyl acetal of 2-[1-chloromethyl-3-(5-chloromethyl-1,3,4-thiadiazol-2-yl)ureido]-3-methoxypropionaldehyde.

Provenance & Evidence