5-Allyl-1,3,4-thiadiazol-2-yl isocyanate → HCID 20357015, compound

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Reaction Steps

5-Allyl-1,3,4-thiadiazol-2-yl isocyanate dimer (0.05 mole), the dimethyl acetal of 2-γ-bromopropylamino-3-methoxypropionaldehyde (0.1 mole) and benzene (60 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux for a period of about 30 minutes. After this time the mixture is stripped of benzene under reduced pressure to yield a solid product as the residue. This residue is then recrystallized to yield the desired product 2-[1-γ-bromopropyl-3-(5-allyl-1,3,4-thiadiazol-2-yl)-ureido]-3-methoxypropionaldehyde.

Provenance & Evidence