2-(Methylamino)acetaldehyde → HCID 20357146, compound

HRID 2083636Notes

Reaction equation

HRID 2083636 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]=[C:11]=[O:12].[CH3:13][NH:14][CH2:15][CH:16]=[O:17]>C1C=CC=CC=1>[CH3:13][N:14]([CH2:15][CH:16]=[O:17])[C:11]([NH:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[O:12]

Participants

4

Reactant 2

HCID 133161322-(Methylamino)acetaldehydeHCID 18916378HCID 18916378, compound

Product 1

HCID 20357146HCID 20357146, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Benzothiazol-2-yl isocyanate dimer prepared in Example 1, benzene (300 ml) and the dimethyl acetal of 2-methylaminoacetaldehyde (80 grams; 0.67 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is stirred at room temperature for a period of about one hour. After this time the mixture is filtered to remove a yellow solid that has formed. The filtrate is then stripped of solvent under reduced pressure to yield the desired product the dimethyl acetal of 2-(1-methyl-3-benzothiazol-2-ylureido)acetaldehyde as an oil.

Workup

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the mixture is filtered
  3. customto remove a yellow solid that
  4. customhas formed

Sources & evidence

ORD record
ord-fd64a287c0bb4d52a46b6d49e6ac00c0
Source dataset
uspto-grants-1978_04
Patent number
US04086241

Reaction notes

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