5,6-Dichlorobenzothiazol-2-yl isocyanate → HCID 54243109, compound

HRID 2083648Notes

Reaction equation

HRID 2083648 reaction equation
[Cl:1][C:2]1[C:3]([Cl:14])=[CH:4][C:5]2[S:9][C:8]([N:10]=[C:11]=[O:12])=[N:7][C:6]=2[CH:13]=1.[Br:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]=[O:21]>C1C=CC=CC=1>[Br:15][CH2:16][CH2:17][N:18]([CH2:19][CH:20]=[O:21])[C:11]([NH:10][C:8]1[S:9][C:5]2[CH:4]=[C:3]([Cl:14])[C:2]([Cl:1])=[CH:13][C:6]=2[N:7]=1)=[O:12]

Participants

4

Reactant 2

HCID 540279235,6-Dichlorobenzothiazol-2-yl isocyanateHCID 54272806HCID 54272806, compound

Product 1

HCID 54243109HCID 54243109, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

5,6-Dichlorobenzothiazol-2-yl isocyanate dimer (0.1 mole), the dimethyl acetal of 2-β-bromoethylaminoacetaldehyde (0.2 mole) and benzene (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is stirred at ambient temperatures for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent to yield the desired product the dimethyl acetal of 2-[1-β-bromoethyl-3-(5,6-dichlorobenzothiazol-2-yl)ureido]-acetaldehyde as the residue.

Workup

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered

Sources & evidence

ORD record
ord-2cdb8811b3ef4eada79a07f7d5db405d
Source dataset
uspto-grants-1978_04
Patent number
US04086241

Reaction notes

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