反应详情

A mixture 3,4-dibenzyloxyphenacyl bromide (32.8 g.), N-[2-(4-carbamoylmethylphenoxy)ethyl]benzylamine (22.8 g.), anhydrous sodium carbonate (8.4 g.) and ethanol (1 liter) was boiled under reflux for 3 hours, then filtered hot to remove the inorganic sediment and evaporated in vacuo to afford a thick syrup. The latter was crystallized upon trituration in diethyl ether and a sample of the resultant solid was recrystallized from ethanol to give N-benzyl-N-(3,4-dibenzyloxybenzoyl)methyl-2-(4-carbamoylmethylphenoxy)ethylamine, m.p. 99°-101° C.

1. temperatureunder reflux for 3 hours
2. filtrationfiltered hot
3. customto remove the inorganic sediment
4. customevaporated in vacuo
5. customto afford a thick syrup
6. customThe latter was crystallized upon trituration in diethyl ether
7. customa sample of the resultant solid was recrystallized from ethanol