Potassium Hydroxide → HCID 14744528, compound

HRID 2083728Notes

Reaction equation

HRID 2083728 reaction equation
[CH2:1]([O:3][C:4]1([O:16][CH2:17][CH3:18])[CH2:9][CH:8](C(OCC)=O)[C:7](=[O:15])[CH2:6][CH2:5]1)[CH3:2].[OH-].[K+]>>[CH2:17]([O:16][C:4]1([O:3][CH2:1][CH3:2])[CH2:9][CH2:8][C:7](=[O:15])[CH2:6][CH2:5]1)[CH3:18]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 20357555HCID 20357555, compound

Product 1

HCID 14744528HCID 14744528, compound

Procedure

Into a flask are successively added 38.7 g of ethyl 5,5-diethoxy-2-oxocyclohexane carboxylate and 215 ml of a 10% potassium hydroxide solution. The mixture is refluxed for 16 hours, then cooled to room temperature. The organic phase is extracted twice with ether; the aqueous solution is salted out with potassium carbonate and an oily phase separates which is extracted with ether. The ethereal phases are united, dried over potassium carbonate and evaporated to dryness. The crude residue weighing 26.4 g is purified by distillation under reduced pressure. The yield amounts to 22.3 g of a liquid boiling at 110°-112° under 12 mm Hg -- nD22 = 1.449.

Workup

  1. customInto a flask are successively added
  2. temperatureThe mixture is refluxed for 16 hours
  3. extractionThe organic phase is extracted twice with ether
  4. extractionan oily phase separates which is extracted with ether
  5. dry with materialdried over potassium carbonate
  6. customevaporated to dryness
  7. distillationis purified by distillation under reduced pressure

Sources & evidence

ORD record
ord-32baa845a1ca4a8d97f480a62c8ec25c
Source dataset
uspto-grants-1978_04
Patent number
US04086355

Reaction notes

Loading…