HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone → 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-propylaminocarbonyloxy-isoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Propylamine | HCID 7852 | — |
| Product | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-propylaminocarbonyloxy-isoindolin-1-one | HCID 22754717 | 178.4% |
Reaction Steps
Following the procedure of Example 1 but starting with 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and a 40% (w/v) aqueous solution of propylamine (8.75 cc.) in acetonitrile (200 cc.), 2-(7-chloro-1,8-naphthyridin-2-yl)-3-propylaminocarbonyloxy-isoindolin-1-one (4.7 g.), melting at 208°-209° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04086348 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-0752a7d6a671409ca9299709d43cbe57 |
| Source note | uspto-grants-1978_04 |