HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2083751Generated: October 25, 2026
Propionic Acid → 4-(2-Chloro-9-xanthenylidene)-1-methylpiperidine maleate
https://huagongshe.com/reaction/2083751
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 9H-Xanthen-9-ol, 2-chloro-9-(1-methyl-4-piperidinyl)- | HCID 11809663 | — |
| Reactant | Sulphobenzoic anhydride | HCID 13795534 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Chloro-9-xanthenylidene)-1-methylpiperidine maleate | HCID 70613469 | — |
Reaction Steps
A mixture of 12.5 g. (0.038 m.) of the xanthene-9-ol, 14.0 g. (0.76 m.) of o-sulfobenzoic anhydride and 380 ml. of propionic acid is refluxed for three hours. The reaction mixture is heated in vacuo at 100° C. and the resulting syrup is dissolved in water, made strongly basic with 40% sodium hydroxide solution, extracted with ether, and the dried extract is evaporated. The residual free base is dissolved in ethyl acetate and maleic acid (4.4 g.) is added to yield 4-(2-chloro-9-xanthenylidene)-1-methylpiperidine maleate, m.p. 206°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04086350 |
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| Source dataset | uspto-grants-1978_04 |
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| ORD ID | ord-2c4b050a73984c9c8316ee23d073ec72 |
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| Source note | uspto-grants-1978_04 |
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