HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Trifluoromethyl-xanthen-9-one → 9-(1-Methylpiperidin-4-YL)-2-(trifluoromethyl)-9H-xanthen-9-OL
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Trifluoromethyl-xanthen-9-one | HCID 2760787 | — |
| Reactant | 4-Chloro-1-methylpiperidinium chloride | HCID 3034158 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 9-(1-Methylpiperidin-4-YL)-2-(trifluoromethyl)-9H-xanthen-9-OL | HCID 20357529 | — |
Reaction Steps
The Grignard reagent from 68 g. (0.4 m.) of 4-chloro-N-methylpiperidine hydrochloride and 9.7 g. (0.4 m.) of magnesium turnings in a total volume of 250 ml. of tetrahydrofuran is obtained following the procedure of Example 3. After all the halide is added, 75.6 g. (0.287 m.) of 2-trifluoromethylxanthone is added portionwise and refluxing/stirring are continued for one hour under nitrogen. The reaction mixture is quenched on ice-water-ammonium chloride to give 9-(1-methyl-4-piperidyl)-2-trifluoromethylxanthene-9-ol, m.p. 179°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04086350 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-2eac4c89d7b348c9b6e4300edb3a51f4 |
| Source note | uspto-grants-1978_04 |