HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2083753Generated: October 26, 2026
Propionic Acid → 1-Methyl-4-[2-(trifluoromethyl)-9H-xanthen-9-ylidene]piperidine
https://huagongshe.com/reaction/2083753
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sulphobenzoic anhydride | HCID 13795534 | — |
| Reactant | 9-(1-Methylpiperidin-4-YL)-2-(trifluoromethyl)-9H-xanthen-9-OL | HCID 20357529 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Methyl-4-[2-(trifluoromethyl)-9H-xanthen-9-ylidene]piperidine | HCID 20357514 | — |
Reaction Steps
Dehydration of the xanthene-9-ol (88.2 g., 0.24 m.) is accomplished by refluxing with 88.1 g. (0.48 m.) of sulfobenzoic anhydride and 1.2 1. of propionic acid for two hours. The reaction mixture is heated in vacuo at 100° C. and the residual syrup is dissolved in water and made strongly basic with 40% sodium hydroxide solution. Extraction with ether gives 1-methyl-4-(2-trifluoromethyl-9-xanthenylidene)-piperidine, m.p. 82°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04086350 |
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| Source dataset | uspto-grants-1978_04 |
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| ORD ID | ord-ede74644681e4b3aac23b61d8e71411c |
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| Source note | uspto-grants-1978_04 |
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