HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2-Fluoro-9-(1-methylpiperidin-4-YL)-9H-xanthen-9-OL
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-chloro-N-methylpiperidine | HCID 79342 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | 2-Fluoro-9H-xanthen-9-one | HCID 11600956 | — |
| Product | 2-Fluoro-9-(1-methylpiperidin-4-YL)-9H-xanthen-9-OL | HCID 20357505 | — |
Reaction Steps
The Grignard reagent prepared from 0.53 g. (0.0216 m.) of magnesium and 2.9 g. (0.0216 m.) of 4-chloro-N-methylpiperidine is reacted with 2.3 g. (0.0108 m.) of 2-fluoroxanthone as described in Example 3. The reaction mixture is heated for four hours and then decomposed with saturated ammonium chloride solution to yield 2-fluoro-9-(1-methyl-4-piperidyl)-xanthene-9-ol, m.p. 193°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04086350 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-cc9d9e696613425293869ce30d789a4d |
| Source note | uspto-grants-1978_04 |