Benzene → HCID 20357471, compound

Participants

Reaction Steps

Similarly, 6.3 g. (0.02 mol) of 4-(2-chloro-9-thioxanthenylidene)piperidine in 30 ml. of benzene is treated with a solution of 1.2 g. (0.01 mol) of cyclobutylcarboxylic acid chloride in 10 ml. of benzene. Following the above workup procedure, the intermediate amide is reduced with 1.5 g. (0.04 mol) of lithium aluminum hydride in 50 ml. of ether. After isolation of the amine product, the ether is evaporated in vacuo and a hexamate salt formed of 4-(2-chloro-9-thioxanthenylidene)-1-cyclobutylmethylpiperidine, m.p. 180°-182° C.

Provenance & Evidence