HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloro-N-methylpiperidine → 6-Chloro-2-fluoro-9-(1-methylpiperidin-4-yl)-9H-thioxanthen-9-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloro-N-methylpiperidine | HCID 79342 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | 6-Chloro-2-fluoro-9H-thioxanthen-9-one | HCID 70613798 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Chloro-2-fluoro-9-(1-methylpiperidin-4-yl)-9H-thioxanthen-9-ol | HCID 20357482 | — |
Reaction Steps
The Grignard reagent prepared from 5.9 g. (0.044 mol) of 4-chloro-N-methylpiperidine and 1.1 g. (0.044 mol) of magnesium turnings of tetrahydrofuran is treated with 5.8 g. (0.022 mol) and the above-prepared thioxanthone. The mixture is refluxed for four hours and worked up by the usual procedure to yield 6-chloro-2-fluoro-9-(1-methyl-4-piperidyl)-thioxanthene-9-ol, m.p. 133°-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04086350 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-d09dbcb27278448d8dc5e8a4ec586e8e |
| Source note | uspto-grants-1978_04 |