HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2,6-Difluoro-9-(1-methylpiperidin-4-YL)-9H-thioxanthen-9-OL
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-chloro-N-methylpiperidine | HCID 79342 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | 2,6-Difluoro-9H-thioxanthen-9-one | HCID 20357484 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,6-Difluoro-9-(1-methylpiperidin-4-YL)-9H-thioxanthen-9-OL | HCID 20357479 | — |
Reaction Steps
The Grignard reagent prepared from 2.7 g. (0.02 mol) of 4-chloro-N-methylpiperidine and 0.5 g. (0.02 mol) of magnesium turnings in tetrahydrofuran is treated with 2.5 g. (0.01 mol) of 2,6-difluorothioxanthone at a rate to maintain slow reflux. The mixture is refluxed for six hours, hydrolyzed with saturated ammonium chloride solution and extracted with ether to yield 2,6-difluoro-9-(1-methyl-4-piperidyl)-thioxanthene-9-ol, m.p. 207°-209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04086350 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-8ef1ec4c11af45f8b00f522d2b3e915a |
| Source note | uspto-grants-1978_04 |