Propionic Acid → 4-(2,6-Difluoro-9H-thioxanthen-9-ylidene)-1-methylpiperidine

HRID 2083771Notes

Reaction equation

HRID 2083771 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[C:9]([F:16])[CH:10]=3)[C:5]([CH:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)(O)[C:4]=2[CH:3]=1.S(C1C=CC=CC=1C(OC(=O)C1C=CC=CC=1S(O)(=O)=O)=O)(O)(=O)=O.C(O)(=O)CC>>[F:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[C:9]([F:16])[CH:10]=3)[C:5](=[C:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 13795534Sulphobenzoic anhydrideHCID 203574792,6-Difluoro-9-(1-methylpiperidin-4-YL)-9H-thioxanthen-9-OL

Product 1

HCID 203575304-(2,6-Difluoro-9H-thioxanthen-9-ylidene)-1-methylpiperidine

Procedure

The thioxanthene-9-ol (2.6 g., 0.0075 mol) prepared as above is heated with 2.8 g. (0.015 mol) of o-sulfobenzoic anhydride in 80 ml. of propionic acid. The product is isolated by the usual procedure to give 4-(2,6-difluoro-9-thioxanthenylidene)-1-methylpiperidine, m.p. 120°-123° C.

Workup

  1. temperatureabove is heated with 2.8 g
  2. customThe product is isolated by the usual procedure

Sources & evidence

ORD record
ord-c69734512e314c74b321adb0e585f9e9
Source dataset
uspto-grants-1978_04
Patent number
US04086350

Reaction notes

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