HCID 54097802, compound → HCID 54560982, compound

HRID 2083819Notes

Reaction equation

HRID 2083819 reaction equation
[CH3:1][O:2][C:3](=[O:63])[C@H:4]([CH2:59][CH:60]([CH3:62])[CH3:61])[NH:5][C:6](=[O:58])[C@@H:7]([CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)[NH:8][C:9](=[O:50])[C@H:10]([CH2:42][C:43]1[CH:48]=[CH:47][C:46]([OH:49])=[CH:45][CH:44]=1)[NH:11][C:12](=[O:41])[C@H:13]([CH2:39][OH:40])[NH:14][C:15](=[O:38])[C@H:16]([CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[NH:31][CH:30]=1)[NH:17]C(OCC1C=CC=CC=1)=O>[Pd].CO>[CH3:1][O:2][C:3](=[O:63])[C@H:4]([CH2:59][CH:60]([CH3:61])[CH3:62])[NH:5][C:6](=[O:58])[C@@H:7]([CH2:51][C:52]1[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=1)[NH:8][C:9](=[O:50])[C@H:10]([CH2:42][C:43]1[CH:48]=[CH:47][C:46]([OH:49])=[CH:45][CH:44]=1)[NH:11][C:12](=[O:41])[C@H:13]([CH2:39][OH:40])[NH:14][C:15](=[O:38])[C@H:16]([CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[NH:31][CH:30]=1)[NH2:17]

Participants

4

Reactant 1

HCID 54097802HCID 54097802, compound

Product 1

HCID 54560982HCID 54560982, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Nα -benzyloxycarbonyl-L-tryptophyl-L-seryl-L-tyrosyl-D-Phenylalanyl-L-leucine methyl ester, 6.0 g., is dissolved in 140 ml. of absolute methanol and 800 mg. of 20% palladium-on-carbon added. The mixture is reduced under a hydrogen atmosphere, monitoring by thin layer chromatography. The catalyst is removed by filtration using a filter aid (Super-Cel). The solvent is evaporated to leave a solid residue which is dried under reduced pressure and used without further treatment.

Workup

  1. dissolution, is dissolved in 140 ml
  2. customThe catalyst is removed by filtration
  3. customThe solvent is evaporated
  4. customto leave a solid residue which
  5. customis dried under reduced pressure

Sources & evidence

ORD record
ord-5cb822bb7c9643b2b8afa63ac2e66016
Source dataset
uspto-grants-1978_04
Patent number
US04086219

Reaction notes

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