Hydrochloric Acid → HCID 70166468, compound

Participants

Reaction Steps

Methanol (70 ml.) containing 6.67 ml. of 3N hydrogen chloride in tetrahydrofuran is added to a mixture of 8.328 g. of Nα -benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [cf. Fischer and Whetstone, J. Am. Chem. Soc., 76, 5076 (1954)] and 500 mg. of 20% palladium-on-carbon and the resulting mixture stirred under hydrogen at one inch water pressure for three hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated to dryness under reduced pressure to give a residue of L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

Provenance & Evidence