HCID 178479460, compound → HCID 178479458, compound

HRID 2083824Notes

Reaction equation

HRID 2083824 reaction equation
[ClH:1].C(OC([NH:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:20])[NH2:19])=O)C1C=CC=CC=1>[Pd].CO>[ClH:1].[NH2:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:20]

Participants

4

Reactant 1

HCID 178479460HCID 178479460, compound

Product 1

HCID 178479458HCID 178479458, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 21.2 g. of Nα -benzyloxycarbonyl-L-arginyl-L-prolyl-glycinamide hydrochloride (Example 1, part m) in 200 ml. of methanol with 1.0 g. of 20% palladium-on-carbon is stirred under hydrogen gas for four hours and allowed to stand overnight. The solution is filtered and the filtrate evaporated at 40° C. under reduced pressure to a white foam which is suitable for use without further purification.

Workup

  1. filtrationThe solution is filtered
  2. customthe filtrate evaporated at 40° C. under reduced pressure to a white foam which
  3. customis suitable for use without further purification

Sources & evidence

ORD record
ord-2e9bf0fd78c44f3cbdbb4c1db92e6ae0
Source dataset
uspto-grants-1978_04
Patent number
US04086219

Reaction notes

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