5-Benzyloxyindole → 1-[5-(Benzyloxy)-1H-indol-3-yl]ethan-1-one
Reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][C:19](N(C)C)=[O:20].O=P(Cl)(Cl)Cl>>[C:19]([C:12]1[C:11]2[C:15](=[CH:16][CH:17]=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)[NH:14][CH:13]=1)(=[O:20])[CH3:18]Participants
3
Procedure
In a manner similar to that described in Reference example 1, 5-benzyloxyindole was reacted with DMA/POCl3 to give 3-acetyl-5-benzyloxyindole.
Sources & evidence
- ORD record
- ord-6187c78173e4444ebf97855c13115aaa
- Source dataset
- uspto-grants-2004_04
- Patent number
- US06716605B2
Reaction notes
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