2-Chloro-4-(1,2,3,4-tetrahydroquinolin-1-yl)pyrimidine → 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}pyrimidine

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Reaction Steps

Using an analogous method to that described in Example 1, but starting from 4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]aniline hydrochloride (Method 1) and 2-chloro-4-(1,2,3,4-tetrahydroquinolin-1-yl)pyrimidine (Method 8), the product was obtained. NMR: 1.8-2.0 (m, 2H), 2.19 (s, 6H), 2.2-2.3 (m, 1H), 2.3-2.45 (m, 1H), 2.7-2.8 (m, 2H), 3.7-3.9 (m, 5H), 5.7 (m, 1H), 6.35 (m, 2H), 6.8 (m, 2H), 7.0-7.05 (m, 1H), 7.1-7.2 (m, 2H), 7.35-7.4 (m, 1H), 7.5-7.6 (m, 2H), 7.9-8.0 (m, 2H), 8.95 (s, 1H); MS (MH+): 420.5.

Provenance & Evidence