HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 69888880, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Heptane | HCID 8900 | — |
| Reactant | HCID 22731979 | HCID 22731979 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | HCID 69888880 | HCID 69888880 | — |
Reaction Steps
The enantiomers of 6,8-dichloro-4-hydroxychromane-4-yl-carboxylic acid (2.17 g, 7.77 mmol; from step (v) above) were separated using chiral chromatography (Kromasil TBB; heptane: ethyl acetate: formic acid) affording 0.74 g of the faster moving, not wanted S-enantiomer, and 0.72 g (66%) of the slower moving sub-title compound. ee=98.4%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716834B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-211253072c7246ee8ec386dcc0b1f833 |
| Source note | uspto-grants-2004_04 |