HCID 69694334, compound → HCID 10475786, compound

HRID 2083921Notes

Reaction equation

HRID 2083921 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[O:19][C:20]=2[CH3:21])=[CH:9][C:8]=1[OH:28])[CH3:2]>[Pd]>[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[O:19][C:20]=2[CH3:21])=[CH:9][C:8]=1[OH:28])[CH3:2]

Participants

3

Reactant 1

HCID 69694334HCID 69694334, compound

Product 1

HCID 10475786HCID 10475786, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-{2-Hydroxy-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-acrylic acid ethyl ester (4.0 g, 10.1 mmol) was hydrogenated over 10% palladium on carbon under an atmosphere of hydrogen. Filtration and evaporation provided the title compound in quantitative yield. MS m/z 396 (M+H)+.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-342ca645e3a3417da8759d95715111f6
Source dataset
uspto-grants-2004_04
Patent number
US06716842B2

Reaction notes

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