HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-methoxybenzoyl chloride → N3-(3-Fluoro-4-methoxybenzoyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethyl)-2,3-pyridinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-methoxybenzoyl chloride | HCID 2779255 | — |
| Reactant | N2-[1-(4-pyridyl)piperidin-4-ylmethyl]-2,3-pyridinediamine | HCID 12150690 | — |
| Product | N3-(3-Fluoro-4-methoxybenzoyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethyl)-2,3-pyridinediamine | HCID 9932680 | 25.6% |
Reaction Steps
Using a similar procedure to that described in Example 2, Part D, N2-[1-(4-pyridyl)piperidin-4-ylmethyl]-2,3-pyridinediamine (300 mg, 1.06 mmol) and 3-fluoro-4-methoxybenzoyl chloride (200 mg, 1.17 mmol) yielded 118 mg (15%) of the title compound as a hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716839B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-7d90349bbdd74437abbf3e4fe7f8aac7 |
| Source note | uspto-grants-2004_04 |