HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-N-(4-methoxyphenyl)-3-pyridinecarboxamide → N-(4-Methoxyphenyl)-2-[1-(4-pyridyl)piperidin-4-ylmethyl]aminopyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-N-(4-methoxyphenyl)-3-pyridinecarboxamide | HCID 840301 | — |
| Reactant | [1-(Pyridin-4-yl)piperidin-4-yl]methanamine | HCID 10607746 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(4-Methoxyphenyl)-2-[1-(4-pyridyl)piperidin-4-ylmethyl]aminopyridine-3-carboxamide | HCID 9844870 | 24% |
Reaction Steps
A pressure tube (Aldrich) was charged with 2-chloro-N-(4-methoxyphenyl)pyridine-3-carboxamide (139 mg, 0.524 mmol), 1-(4-pyridyl)piperidine-4-methylamine (100 mg, 0.524 mmol), triethylanine (0.22 mL), and ethanol (3 mL). The mixture was placed in a 110° C. bath for 5 days. The mixture was concentrated and the residue purified by RPHPLC, yielding 52 mg (24%) of the title compound as a hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716839B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-b452d6c4f5684e5590dd84427971d464 |
| Source note | uspto-grants-2004_04 |