Methanesulfonyl chloride → HCID 178505166, compound

HRID 2083969Notes

Reaction equation

HRID 2083969 reaction equation
C(OC([NH:11][C@H:12]([C:20]([OH:22])=O)[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:19])[NH2:18])=O)C1C=CC=CC=1.[CH3:23][S:24]([Cl:27])(=[O:26])=[O:25].[ClH:28].[C:29]([C@@H:31]1[CH2:35][CH2:34][CH2:33][NH:32]1)#[N:30]>>[ClH:27].[ClH:28].[C:29]([C@@H:31]1[CH2:35][CH2:34][CH2:33][N:32]1[C:20](=[O:22])[C@H:12]([CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:19])[NH:18][S:24]([CH3:23])(=[O:26])=[O:25])[NH2:11])#[N:30]

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 44593801(2S)-Pyrrolidine-2-carbonitrile hydrochlorideHCID 178512917HCID 178512917, compound

Product 1

HCID 178505166HCID 178505166, compound

Procedure

Starting from (S)-N2-(benzyloxycarbonyl)-arginine, methanesulphonyl chloride and (S)-2-cyano-pyrrolidine hydrochloride, the expected product is obtained according to the procedure described in Example 1.

Sources & evidence

ORD record
ord-4b124881a30941388bb4e5a7ffade397
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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