Methanesulfonyl chloride → HCID 69891006, compound

HRID 2083970Notes

Reaction equation

HRID 2083970 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24](O)=[O:25])[NH:16]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH3:27][S:28]([Cl:31])(=[O:30])=[O:29].Cl.[C:33]([C@@H:35]1[CH2:39][CH2:38][CH2:37][NH:36]1)#[N:34]>>[ClH:31].[NH2:16][C@H:15]([C:24](=[O:25])[N:36]1[CH2:37][CH2:38][CH2:39][C@H:35]1[C:33]#[N:34])[CH2:14][CH2:13][CH2:12][NH:11][S:28]([CH3:27])(=[O:30])=[O:29]

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 7269338(2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoic acidHCID 44593801(2S)-Pyrrolidine-2-carbonitrile hydrochloride

Product 1

HCID 69891006HCID 69891006, compound

Procedure

Starting from (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine, methanesulphonyl chloride and (S)-2-cyano-pyrrolidine hydrochloride, the expected product is obtained according to the procedure described in Example 3.

Sources & evidence

ORD record
ord-e79335cfdc2644e4a04a80d04512b192
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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