Methanesulfonyl chloride → HCID 178505167, compound

HRID 2083971Notes

Reaction equation

HRID 2083971 reaction equation
C(OC([NH:11][C@H:12]([C:20]([OH:22])=O)[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:19])[NH2:18])=O)C1C=CC=CC=1.[CH3:23][S:24]([Cl:27])(=[O:26])=[O:25].[C:28]([C@@H:30]1[CH2:34][S:33][CH2:32][NH:31]1)#[N:29]>>[ClH:27].[C:28]([C@@H:30]1[CH2:34][S:33][CH2:32][N:31]1[C:20](=[O:22])[C@H:12]([CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:19])[NH:18][S:24]([CH3:23])(=[O:26])=[O:25])[NH2:11])#[N:29]

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 2757982HCID 2757982, compoundHCID 178512917HCID 178512917, compound

Product 1

HCID 178505167HCID 178505167, compound

Procedure

Starting from (S)-N2-(benzyloxycarbonyl)-arginine, methanesulphonyl chloride and (R)-4-cyano-1,3-thiazolidine, the expected product is obtained according to the procedure described in Example 1.

Sources & evidence

ORD record
ord-4c8a5f869a944479977ddf8b6261c222
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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