Cyclohexanesulfonyl chloride → HCID 69890672, compound

HRID 2083981Notes

Reaction equation

HRID 2083981 reaction equation
C(O[C:9]([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([OH:26])=O)[NH:16]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH:27]1([S:33]([Cl:36])(=[O:35])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1.Cl.[C:38]([C@@H:40]1[CH2:44][CH2:43][CH2:42][NH:41]1)#[N:39]>>[ClH:36].[NH2:16][C@H:15]([C:24](=[O:26])[N:41]1[CH2:42][CH2:43][CH2:44][C@H:40]1[C:38]#[N:39])[CH2:14][CH2:13][CH2:12][N:11]([CH3:9])[S:33]([CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)(=[O:35])=[O:34]

Participants

4

Reactant 3

HCID 237554Cyclohexanesulfonyl chlorideHCID 7269338(2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoic acidHCID 44593801(2S)-Pyrrolidine-2-carbonitrile hydrochloride

Product 1

HCID 69890672HCID 69890672, compound

Procedure

Starting from (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine, cyclohexanesulphonyl chloride and (S)-2-cyano-pyrrolidine hydrochloride, the expected product is obtained according to the procedure described in Example 68.

Sources & evidence

ORD record
ord-9dadd3feaa0240a2b2b969292d9f28a9
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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