(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid → HCID 12085095, compound

Participants

Reaction Steps

44.2 g (250 mmol) of 1,2,3,4-tetrahydroisoquinoline-3-(R)-carboxylic acid were dissolved in 500 ml of 1N aqueous sodium hydroxide solution and, while stirring, 150 g (300 mmol) of 4′-nitrobiphenyl-4-sulfonyl chloride dissolved in 500 ml of tetrahydrofuran were added. During this, the reaction temperature was kept below 25° C., and the pH of the solution was adjusted to pH 10 by adding 1N NaOH. The reaction mixture was stirred at room temperature for 12 hours (h).

Provenance & Evidence