Isopropyl iodide → HCID 10130811, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydride (12.7 mg, 0.531 mmol) was added to an ice-cooled solution 6-(2-(N,N-Dimethylamino)ethyl)-1H-indole (50 mg, 0.265 mmol) in DMF (1 ml). After stirring for 1 h at 0° C., 2-iodopropane (52.9 μL, 0.530 mmol) was added and the mixture stirred at 100° C. overnight. The reaction mixture was then partitioned between water and dichloromethane, the organic layer washed sequentially with water and brine, dried over sodium sulfate and the solvent was removed in vacuo. Flash chromatography (silica gel, 7% methanolic ammonia in dichloromethane) gave the title product (10 mg, 16%).

Provenance & Evidence