4-Fluoroiodobenzene → HCID 9861355, compound

Participants

Reaction Steps

A mixture of 6-(1-Methyl-1,2,5,6-tetrahydropyridin-4-yl)-indole (20.1 mg, 0.0945 mmol), potassium carbonate (K2CO3; 52.3 mg, 0.3787 mmol), cuprous bromide (CuBr; 6.7 mg, 0.0473 mmol), a little copper powder and 1-fluoro4-iodobenzene (42.04 mg, 0.189 mmol) in 1 ml of N-methyl-4-piperidone (NMP) was heated at 170° C., under argon, overnight. After cooling, the mixture was diluted with dichloromethane and the organic layer washed with water 10 times before being passed through a silica gel column (eluting with 1% 2M ammonia/methanol in dichloromethane) to give the title product (15 mg, 55%).

Provenance & Evidence