HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2084059Generated: October 31, 2026
2-Methylpiperazine → 6-(3-Methylpiperazinyl)-1-triisopropylsilyl-indole
https://huagongshe.com/reaction/2084059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | 6-bromo-1-(triisopropylsilyl)-1H-indole | HCID 12991243 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 6-(3-Methylpiperazinyl)-1-triisopropylsilyl-indole | HCID 10339213 | — |
Reaction Steps
From 6-Bromo-1-triisopropylsilyl-indole (400 mg, 1.14 mmol), 2-methylpiperazine (1.36 mg, 13.6 mmol), NaOtBu (0.153 mg, 1.59 mmol), tBu3P (12 mg) and Pd(OAc)2 (3 mg) in xylene (1 ml) under argon. The reaction mixture was heated to 120° C. (59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06716837B1 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-d180ad88bc724dbfa90aacf8be0f1e03 |
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| Source note | uspto-grants-2004_04 |
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