Phosphine → HCID 69883566, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-1-isopropylindole (23.8 mg, 0.1 mmol), sodium-tbutoxide (NaOtBu; 14.1 mg, 0.15 mmol), tri-tbutyl phosphine (tBu3P; 1 mg), palladium acetylacetonate (Pd(OAc)2; 1 mg) and 1-methylpiperazine (60 mg, 0.6 mmol) in xylene (1 ml) under argon was heated at 120° C. for 3 h., The cooled reaction mixture was diluted with dichloromethane, washed with water and the crude product purified by column chromatography on silica gel, eluting with 1% 2M ammonia/methanol in dichloromethane to give (11.3 mg, 44%) of the title compound.

Provenance & Evidence