HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2084063Generated: October 30, 2026
Isopropyl iodide → 1-(1-Methylethyl)-6-(4-methyl-1-piperazinyl)-1H-indole
https://huagongshe.com/reaction/2084063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-(4-methylpiperazin-1-yl)-1H-indole | HCID 9815785 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(1-Methylethyl)-6-(4-methyl-1-piperazinyl)-1H-indole | HCID 9795103 | 83% |
Reaction Steps
A mixture of 6-(4-methylpiperazinyl)-indole (8.3 mg, 0.386 mmol), K2CO3 (21 mg, 0.154 mmol), NaH (3 mg, 0.125 mmol), DMF (0.1 ml) and 2-iodopropane (26.3 μl, 0.154 mmol) in 0.5 ml of toluene was heated to 90-100° C. for 1 hr. After cooling, dichloromethane was added and the mixture passed a silica gel column, eluting with 1% 2M ammonia/methanol in dichloromethane, to give the title compound (8.2 mg, 83% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06716837B1 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-06bd8f7730524473a300b38dcfca9523 |
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| Source note | uspto-grants-2004_04 |
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