4-Fluoroiodobenzene → HCID 9796673, compound

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Reaction Steps

A mixture of 6-(4-Methylpiperazinyl)-indole (14.8 mg, 0.0687 mmol), K2CO3 (37.9 mg, 0.275 mmol), CuBr (4.9 mg, 0.0353 mmol), a little copper powder and 1-Fluoro-4-iodobenzene (30.5 mg, 0.37 mmol) in 1 ml of NMP was heated at 170° C., under argon, overnight. After cooling, the mixture was diluted with dichloromethane and the organic layer washed with water 10 times before being passed through a silica gel column (eluting with 1% 2M ammonia/methanol in dichloromethane) to give the title product (7.8 mg, 37%).

Provenance & Evidence