Benzyloxyamine hydrochloride → HCID 86588584, compound

HRID 2084069Notes

Reaction equation

HRID 2084069 reaction equation
O=[C:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][C:5]1=[O:9].Cl.[CH2:17]([O:24][NH2:25])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][N:25]=[C:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][C:5]1=[O:9])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 102312Benzyloxyamine hydrochlorideHCID 22733081HCID 22733081, compound

Product 1

HCID 86588584HCID 86588584, compoundYield 31%

Procedure

0.3 g (1.47 mmol) of 1-(2-oxo-2-pyridin-3-yl-ethyl)-pyrrolidin-2-one prepared from Example 20 and 0.35 g (2.21 mmol) of benzyloxyamine hydrochloride salt were treated as described in Example 22 to obtain 0.14 g (31% yield) of 1-(2-benzyloxyimino-2-pyridin-3-yl-ethyl)-pyrrolidin-2-one as E/Z mixture (1.02:1).

Sources & evidence

ORD record
ord-66910b0d2e8649558f9d61cd49e02897
Source dataset
uspto-grants-2004_04
Patent number
US06716857B2

Reaction notes

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