HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)aniline → 4-(3-Trifluoromethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)aniline | HCID 73753 | — |
| Reactant | 4-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine | HCID 2763395 | — |
| Product | 4-(3-Trifluoromethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine | HCID 22732353 | — |
Reaction Steps
The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-(trifluoromethoxy)aniline (65 μl, 0.243 mmol) similar to Example 11 and isolated as a pale white solid (78 mg, 93%). 1H NMR (DMSO-d6): 9.95 (s, 1H), 8.74 (s, 1H), 8.31 (d, J=9.3 Hz, 2H), 7.95 (t, J=7.7 Hz, 1H), 7.65 (d, J=8.4 Hz, 1H), 7.53-7.43 (m, 2H), 6.98 (d, J=8.4 Hz, 1H), 6.71 (s, 1H), 2.44 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716851B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-70520f70ced64729a1b865da86388abc |
| Source note | uspto-grants-2004_04 |