3-Isopropylaniline → HCID 9814966, compound

HRID 2084094Notes

Reaction equation

HRID 2084094 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[CH:15]([C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21])([CH3:17])[CH3:16]>>[CH:15]([C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH:21][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 4586793-IsopropylanilineHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

Product 1

HCID 9814966HCID 9814966, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-isopropylaniline (33 μl, 0.243 mmol) similar to Example 13 and isolated as a gray oil (70 mg, 95%). 1H NMR (CDCl3): 8.79-8.77 (m, 1H), 8.47-8.43 (m, 1H), 7.81-7.75 (m, 1H), 7.35-7.25 (m, 3H), 7.17-7.12 (m, 2H), 7.02 (d, J=7.5 Hz, 1H), 2.93-2.84 (m, 1H), 2.45 (s, 3H), 1.24 (d, J=6.9 Hz, 6H).

Sources & evidence

ORD record
ord-4cbe3c197e744428b0df9844c788d2b6
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

Loading…