HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyaniline → 4-(3-Methoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Reactant | 4-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine | HCID 1485989 | — |
| Product | 4-(3-Methoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine | HCID 22732434 | — |
Reaction Steps
The title compound was prepared from a mixture of 4-chloro-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and m-anisidine (22 μl, 0.193 mmol) similar to Example 13 and isolated as a yellow solid (31 mg, 46%). 1H NMR (CDCl3): 8.77-8.75 (m, 2H), 8.28-8.25 (m, 2H), 7.36 (t, J=8.3 Hz, 1H), 7.13 (s, 1H), 7.03 (s, 1H), 6.98-6.96 (m, 2H), 6.83-6.81 (m, 1H), 3.84 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716851B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-d2beae0675814141abc2919f90004dad |
| Source note | uspto-grants-2004_04 |