4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 22732484, compound

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Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3-(2,3,4,5,6-pentafluorophenoxy)aniline (106 mg, 0.386 mmol) similar to Example 58 and isolated as a yellow solid (65 mg, 68%). 1H NMR (DMSO-d6): 10.46 (s, 1H), 9.24 (s, 1H), 8.75 (dd, J=1.8, 4.8 Hz, 1H), 8.56-8.52 (m, 1H), 7.77 (s, 1H), 7.59-7.55 (m, 1H), 7.50-7.41 (m, 2H), 7.14 (s, 1H), 6.94-6.92 (m, 1H).

Provenance & Evidence