HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenoxyaniline → 4-(3-Phenoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenoxyaniline | HCID 77135 | — |
| Reactant | 4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine | HCID 1485990 | — |
| Product | 4-(3-Phenoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine | HCID 22732371 | — |
Reaction Steps
The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3-phenoxyaniline (71 mg, 0.386 mmol) similar to Example 58 and isolated as a pale white solid (33 mg, 42%). 1H NMR (CDCl3): 9.74 (d, J=2.1 Hz, 1H), 8.72-8.66 (m, 2H), 8.52 (bs, 1H), 7.45-7.37 (m, 4H), 7.21-7.10 (m, 5H), 6.97 (s, 1H), 6.93 (dd, J=2.1, 8.1 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716851B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-ddc29073e8044f139fbe00c6e686b1d1 |
| Source note | uspto-grants-2004_04 |