3-Aminophenol → HCID 22732526, compound

HRID 2084121Notes

Reaction equation

HRID 2084121 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[ClH:1].[OH:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 115683-AminophenolHCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732526HCID 22732526, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (89 mg, 0.344 mmol) and 3-aminophenol (30 mg, 0.275 mmol) similar to Example 58 and isolated as a yellow solid (61 mg, 67%). 1H NMR (DMSO-d6): 10.40 (s, 1H), 8.86 (dd, J=0.9, 5.1 Hz, 1H), 8.51 (d, J=7.8 Hz, 1H), 8.32-8.26 (m, 1H), 7.82-7.78 (m, 1H), 7.29 (s, 1H), 7.26 (s, 1H), 7.23 (s, 1H), 7.19 (d, J=7.5 Hz, 1H), 6.57 (dd, J=1.8, 9.0 Hz, 1H).

Sources & evidence

ORD record
ord-3fd07e5da41645978d64c285078ba893
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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