HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → 4-(2-Cyano-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine | HCID 1485990 | — |
| Reactant | 2-Amino-4-methylbenzonitrile | HCID 2801276 | — |
| Product | 4-(2-Cyano-5-methylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine | HCID 10132850 | — |
Reaction Steps
The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 2-cyano-5-methylaniline (38 mg, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (8 mg, 12%). 1H NMR (CDCl3): 9.62-9.61 (m, 1H), 8.75-8.69 (m, 2H), 8.08 (s, 1H), 7.62 (s, 1H), 7.60 (d, J=8.1 Hz, 1H), 7.46-7.41 (m, 1H), 7.12 (dd, J=0.9, 8.1 Hz, 1H), 7.00 (s, 1H), 2.52 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716851B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-5e0e816de6ae45859c8afe7e5c5cdd9f |
| Source note | uspto-grants-2004_04 |